Colchester boss John McGreal is likely to name an unchanged squad when Grimsby visit Essex.
The U’s were 3-0 winners against Plymouth at the weekend and McGreal may be tempted to stick with the same starting line-up.
Midfielder Tom Lapslie remains a doubt due to a knee injury, but Tafari Moore could return to the squad after sitting out the game against his parent club Plymouth.
Long-term absentee Paris Cowan-Hall (Achilles/calf) continues his recovery from injury.
Defender Bradley Garmston could make his Grimsby debut after joining the club on transfer deadline day.
Fellow new signing Elliot Grandin made his first appearance from the bench in the 1-1 draw at Bradford on Saturday but is not yet ready to start.
Jake Hessenthaler is still sidelined while Jordan Cook and Harry Davis are recovering from their injuries, but this game is likely to come too soon.
Ahkeem Rose has not featured since the draw with Leyton Orient on January 11 but is back in training.